Cottbus is a university city and the second-largest city in Brandenburg, Germany. Situated around 125 km (78 mi) southeast of Berlin, on the River Spree, Cottbus is also a major railway junction with extensive sidings/depots. Although only a small Sorbian minority lives in Cottbus itself, the city is considered as the political and cultural center of the Sorbs in Lower Lusatia.

The settlement was established in the 10th century, when Sorbs erected a castle on a sandy island in the River Spree. The first recorded mention of the town's name was in 1156. In the 13th century German settlers came to the town and thereafter lived side by side with the Sorbs. In the Middle Ages Cottbus was known for wool, and the town's drapery was exported throughout Brandenburg, Bohemia and Saxony. In 1445 Cottbus was acquired by the Margraviate of Brandenburg from Bohemia. In 1514 Jan Rak founded the Universitas Serborum, a Sorbian gymnasium, in the city. In 1701 the city became part of the Kingdom of Prussia. It was also ruled by Saxony between 1807 and 1813. In 1815 the surrounding districts of Upper and Lower Lusatia were ceded by the Kingdom of Saxony to Prussia. According to the Prussian census of 1905, the city of Cottbus had a population of 46,270, of which 97% were Germans, 2% were Sorbs and 1% were Poles.

In interwar Germany, the town was the site of a concentration camp for unwanted Jewish immigrants from Eastern Europe.

During World War II, Cottbus was taken by the Red Army on 22 April 1945. From 1949 until German reunification in 1990, Cottbus was part of the German Democratic Republic (East Germany).