Hattersley is an area of Tameside, Greater Manchester, 4 miles (6.4 km) west of Glossop and 10 miles (16 km) east of Manchester city centre at the eastern terminus of the M67. Historically part of Tintwistle Rural District in Cheshire until 1974, it is the site of an overspill estate built by Manchester City Council in the 1960s. Hattersley is an area receiving major regeneration which includes new properties and additional retail stores.

Hattersley is served by train, Hattersley Station and via bus, with frequent services to Manchester City Centre via the 201 bus service.

Between 1894 and 1936, Hattersley was a largely rural civil parish in the Tintwistle Rural District in the historical county of Cheshire. In 1936, it was annexed to the municipal borough of Hyde but remained undeveloped. At the beginning of the 1960s, most of the area was purchased by Manchester City Council to build a large overspill estate, which became home to many families rehoused from inner-city slum areas like Gorton. Another similar estate was built in Gamesley. Both these estates consist primarily of council-built houses.

Moors murderer Myra Hindley and her grandmother Ellen Maybury, together with Hindley's boyfriend Ian Brady, were rehoused in Hattersley from Gorton in 1964 and lived at a new council house in the area - 16 Wardle Brook Avenue - for approximately 12 months until they Hindley and Brady were arrested in October 1965. Brady spent much of his time at the house with Hindley and together they carried out the killings of 10-year-old Lesley Ann Downey and 17-year-old Edward Evans at the house; they had already committed three murders while living in Gorton. The body of Downey was buried on nearby Saddleworth Moor the day after her murder on Boxing Day 1964, It was found in the initial search of the moors nearly a year later, but the body of Edward Evans was found at the house in October 1965 before the couple could dispose of it; the police then found the evidence to link Brady and Hindley to the four earlier murders.

In October 1987, Manchester City Council demolished the house as they could not find tenants willing to live there. The site of the house remains vacant, although the surrounding houses remain standing.